What Health Problems Do MTHFR Anomalies Aggravate?

MTHFR anomalies can have a wide variety of effects. This is partly because of the widespread impact on MTHFR on the body’s metabolism, and partly because each anomaly has slightly different effect, leading to different health problems. In addition, the effects of MTHFR can vary depending on a person’s environment, lifestyle or other metabolic anomalies.

In this article you will find a brief introduction to some of the health problems that MTHFR causes. If you or someone you love is dealing with several of these health problems, especially if there is no clear cause for their illness, it is probably worthwhile to look into getting tested for MTHFR anomalies.

Health Problems Caused by MTHFR
Autism: MTHFR 677 and MTHFR 677/1298 both carry an increased risk of autism. Mothers with MTHFR who do not take folate supplements during pregnancy may be more likely to have children develop autism.

Birth defects: MTHFR 677 is associated with an increased risk of birth defects including neural tube defects and cleft lip.

Cardiovascular disease: One of the most common causes of death, cardiovascular disease affects millions of people world wide. Cardiovascular disease is associated with MTHFR 677.

Hypertension: Elevated blood pressure is more strongly associated with MTHFR 677 than other forms of cardiovascular disease.

Chronic fatigue syndrome: In 2011 it was discovered that there is a virus associated with CFS, and treatments are finally being developed. However there is also a relationship between CFS and MTHFR 1298. Perhaps the MTHFR anomaly in some way prevents the body from fighting off the virus.

Deep venous thrombosis (DVT): Deep vein thrombosis is the medical term for when a blood clot forms in a major vein and blocks blood flow to large parts of the body. Untreated, DVT is potentially fatal. Most often these blood clots form in the legs. MTHFR 677 is associated with an increased risk of developing DVT.

Dementia: Many people, as they get older, slowly lose cognitive functions. Their memory becomes weaker; their judgment and behavior become erratic, they have difficulty speaking or can’t think clearly. Most of the time dementia is a symptom of another illness, such as brain cancer. Sometimes dementia develops for no apparent reason. When no other cause for dementia may be found, in these cases MTHFR 1298 may be a factor.

Depression and anxiety disorders: MTHFR 1298 interferes with serotonin production. Low levels of serotonin are a frequent cause of mental health problems such as anxiety and depressive disorders.

Elevated homocysteine: Homocysteine is an amino acid that is produced by the body when breaking down proteins. High levels of homocysteine are associated with and believed to cause a number of health problems. People with MTHFR 1298 are likely to have high homocysteine levels.

Fibromyalgia: Frequently referred to as ‘fibro’, fibromyalgia is a chronic pain syndrome with no known cause. It frequently occurs alongside chronic fatigue syndrome. Fibro is more common among people with MTHFR 1298.

Heavy metals: People with all MTHFR polymorphisms have trouble clearing heavy metals. This can lead to heavy metal poisoning and the many health problems high levels of heavy metals in the body can cause.

Irritable bowel syndrome (IBS or spastic colon): A bowel disorder associated with cramping, pain, unusual bowl movements and is usually triggered by eating specific foods. IBS is more frequent in people who have MTHFR 1298.

Migraines: Migraines are a specific kind of headache which include pain focused behind the eyes, light sensitivity, ‘auras’ or visual effects, and other symptoms. Many people who have migraines find they are triggered by specific foods, stress and environmental factors. Some kinds of migraines are associated with MTHFR 677.

Oxidative Stress: Techinically, oxidative stress isn’t a health problem in the sense of a disease or medical disorder. Oxidative stress is damage done to the body by free radicals, and over time it leads to a wide variety of additional health problems.

Parkinson’s disease: Parkinson’s is a nervous disorder which interferes with the nerves and slowly destroys both fine and gross motor control. It is also frequently painful. People with the 1298 MTHFR polymorphism are more likely to develop Parkinson’s disease.

Peripheral neuropathy: Peripheral neuropathy is the medical term for when the nerves throughout the body stop functioning properly. This condition is a part of several poorly understood nervous disorders, including multiple sclerosis. MTHFR 677 is associated with increased risk of peripheral neuropathy.

Pre-eclampsia: Pre-eclampsia is a pregnancy complication which develops sometimes when a mother’s blood pressure is very high for an extended period of time. If untreated pre-eclampsia develops into eclampsia, which can lead to early labor and is potentially dangerous for both mother and baby. Mothers with MTHFR 677 are more likely to develop pre-eclampsia.

Renal failure (Acute kidney failure): The kidneys are responsible for filtering the blood, removing wastes and concentrating urine. Sudden (or acute) kidney failure is more likely in people who have any of the MTHFR polymorphisms.

Schizophrenia: Schizophrenia is a mental disorder whose symptoms include paranoia and hallucinations. It occurs more frequently in people who have MTHFR 677.

Stillbirth: A stillbirth is when a fetus dies of natural causes after the 20th week of the pregnancy. Early spontaneous abortion is when the fetus dies of natural causes before the 20th week. Women with MTHFR 677 are more likely to experience a stillbirth or multiple early spontaneous abortions.

Stroke:  When blood flow to an area of the brain is suddenly cut off, parts of the brain are damaged. This is what is known as a stroke. A stroke may occurs when a blood clot forms inside the brain and cuts off blood flow, or when something else interferes with the flow of blood through the brain. An increased risk of stroke is associated with MTHFR 677.

Tetrahydrobiopterin problems: Tetrahydrobiopterin is an amino acid that plays several important roles tin the body’s function. Some people have a deficiency in tetrahydrobiopterin. These deficiencies may cause a variety of neurological problems. Tetrahydrobiopterin problems are more common among people with MTHFR 1298.

Researchers are still working to determine why the MTHFR anomaly may cause these problems. In time, they may find other health problems that are also related to MTHFR. Not everyone who has MTHFR problems will have these health issues, and many people who have some of these health problems do not have an MTHFR anomaly. Having an MTHFR anomaly increases the risk of developing these health problems, but other factors determine whether or not anyone will have a specific health problem. For instance, someone with an MTHFR anomaly will have difficulty clearing heavy metal from their body; but if they are not exposed to heavy metals, they will not get heavy metal poisoning.




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