MTHFR, Oxidative Stress and Glutathione
Glutathione and MTHFR are both important parts of the body’s system for maintaining homeostasis. The complex way the biochemicals of the body interact, means that a problem with one important biochemical will often affect others. In the case of MTHFR anomalies, the inability of the MTHFR enzyme to do its job effectively increases the work load for glutathione, with less than pleasant consequences.
MTHFR Anomalies Create Oxidative Stress
Oxidative stress is damage to the cells of the body by free radicals. Many diseases associated with aging are caused by oxidative stress, as are a number of other health problems. People who have MTHFR anomalies have high levels of oxidative stress.
This is because MTHFR anomalies cause high levels of homocysteine, and homocysteine creates the free radicals that cause oxidative stress.
Oxidative Stress Lowers Glutathione Levels
Glutathione is one of the body’s most powerful anti-oxidants. One of glutathione’s main jobs in the body is to seek out and neutralize free radicals before they can do any damage. Glutathione also helps repair cells and DNA that have already been damaged by free radicals.
When there are more free radicals (which is another way of saying ‘high oxidative stress’) glutathione gets used up faster than usual. If it gets used up fast enough, the body isn’t able to keep up and glutathione levels drop. Then, free radicals are able to damage cells throughout the body, creating the symptoms of oxidative. Low glutathione levels also mean there isn’t enough available to repair damage to cells or help with the other things the body uses it for, like clearing heavy metal.
MTHFR anomalies → high homocysteine → more free radicals → high oxidative stress + low glutathione → many health problems
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